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Background
IKZF1deletion is an unfavorable factor in Philadelphia negative (Ph ‐) B‐cell acute lymphoblastic leukemia. However, the effects of IKZF1 deletions co‐existing genetic alterations in Ph (‐) ALL have not been extensively studied.
Methods
Bone marrow samples from 368 children with Ph (‐) ALL were analyzed by using multiplex ligation‐dependent probe amplification kit for detection of gene...
Background
The leukemogenesis of T‐cell acute lymphoblastic leukemia (T‐ALL) involves multistep processes of genetic alterations. We aimed to determine the genetic alterations including common fusion transcripts, overexpression of T‐cell transcription factor oncogenes, and deletion or mutation of targeted genes in pediatric T‐ALL in Taiwan as well as their impact on outcomes in those treated with...
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