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Noncoding small RNAs, such as microRNAs, are becoming the biomarkers of choice for multiple diseases in clinical diagnostics. A dysregulation of these microRNAs can be associated with many different diseases, such as cancer, dementia, and cardiovascular conditions. The key for effective treatment is an accurate initial diagnosis at an early stage, improving the patient's survival chances. In this...
In article number 1905311, Can Dincer and co‐workers introduce the first CRISPR‐powered electrochemical microfluidic biosensor (CRISPR‐Biosensor), allowing nucleic‐acid‐amplification‐free detection of microRNAs in isolated serum samples. Upon recognition of its target, the activated Cas13a cleaves reporter RNAs in its surroundings, resulting in a decrease of the measured electrochemical signals. The...
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