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Objective
The Reach Ahead for Lifestyle and Health (REAL HEALTH)‐Diabetes study assessed the comparative effectiveness of two Look AHEAD (Action for Health in Diabetes)‐adapted lifestyle intervention (LI) arms targeting weight loss in type 2 diabetes compared with medical nutrition therapy (MNT) referral. At 1 year, LI had greater weight loss than MNT. This study reports outcomes at 24 (end of LI)...
The Breast Cancer Weight Loss (BWEL) trial is a randomized controlled trial designed to determine whether weight loss after a breast cancer diagnosis can reduce the risk of cancer recurrence in women with overweight or obesity. The BWEL trial will compare the efficacy of a telephone‐based weight‐loss intervention plus health education materials versus health education materials alone on invasive disease‐free...
Aim
To test whether diabetes genetic risk modifies the association of successful lifestyle changes with incident diabetes.
Materials and methods
We studied 823 individuals randomized to the intensive lifestyle intervention (ILS) arm of the Diabetes Prevention Programme who were diabetes‐free 1 year after enrolment. We tested additive and multiplicative interactions of a 67‐variant diabetes genetic...
Objective
This study evaluated weight changes after cessation of the 10‐year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2‐year observational period following termination of weight‐loss–maintenance counseling than would participants in the diabetes support and...
Objective
The aim of this study was to characterize weight loss, treatment engagement, and weight control strategies utilized by African American, Hispanic, and non‐Hispanic white participants in the Action for Health in Diabetes (Look AHEAD) Intensive Lifestyle Intervention by racial/ethnic and sex subgroups.
Methods
Weight losses at 1, 4, and 8 years among 2,361 adults with obesity and type 2...
Background
Little is known about the feasibility and impact of lifestyle intervention, determined by change in diet and cardiovascular fitness (CRF), on glycemic control in youth who are overweight with type 2 diabetes. This was examined in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial cohort from across 15 US centers.
Subjects
TODAY enrolled 699 youth...
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