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Caspase-mediated cell death contributes to the pathogenesis of motor neuron degeneration in the mutant SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS), along with other factors such as inflammation and oxidative damage. By screening a drug library, we found that melatonin, a pineal hormone, inhibited cytochrome c release in purified mitochondria and prevented cell death...
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