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The variable region of murine immunoglobulin heavy chain (Igh) is assembled by sequential DH–JH and VH–DJH recombination. The accessibility of the Igh locus determines the order of rearrangement. Because of the large number of VH genes and the lack of a suitable model, the epigenetic modifications of VH genes after DJH recombination have not previously been characterized. Here, we employed two v‐Abl...
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