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PADI4 is one of the human isoforms of a family of enzymes implicated in the conversion of arginine to citrulline. MDM2 is an E3 ubiquitin ligase which is crucial for down‐regulation of degradation of the tumor suppressor gene p53. Given the relationship between both PADI4 and MDM2 with p53‐signaling pathways, we hypothesized they may interact directly, and this interaction could be relevant in the...
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