The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Ideas from System Theory lie behind many of the new powerful methods being developed in the burgeoning field of Systems Biology. In this paper, we show two examples of this: one in the area of stochastic chemical kinetics, and the other in biological model invalidation. Stochastic chemical kinetics has gained a lot of attention in the last few years. In order to capture certain important dynamics...
Intracellular populations of genes, RNA and proteins are often described by continuous-time, discrete-state Markov processes, whose time-varying probability distributions evolve according to the large or infinite dimensional linear ordinary differential equation known as the chemical master equation (CME). Numerical integration and stochastic simulation of the CME are often impossible or time consuming...
Deterministic models fail to capture certain important dynamics in the subcellular environment due to the discrete stochastic nature of the molecular interactions at the gene level. Such discrete stochastic interactions are exploited in the cell to implement stochastic switches whose state are predictable only in a statistical sense. This absence of determinism and the inherent variability resulting...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.