Search results for: Hee-Jung Cho

Items from 1 to 20 out of 34 results

article

Development and validation of a sensitive ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method for quantitative analysis of bambermycin in livestock and aquatic products: Implications for food safety control and regulatory enforcement

Da‐Hee Park, Hee‐Jung Cho, Se‐Hyeong Kang, Hong‐Hee Lee, more

Journal of Separation Science > 46 > 20 > n/a - n/a

A sensitive and accurate analytical method was developed and validated to detect bambermycin, a commonly used antibiotic in animal feed and livestock. The presence of bambermycin residues in food products can pose health risks to consumers, emphasizing the need for a sensitive and accurate analytical method. A reversed‐phase analytical column was utilized with a mobile phase comprising 0.005 mol/L...

article

Gintonin, a Ginseng-Derived Exogenous Lysophosphatidic Acid Receptor Ligand, Protects Astrocytes from Hypoxic and Re-oxygenation Stresses Through Stimulation of Astrocytic Glycogenolysis

Sun-Hye Choi, Hyeon-Joong Kim, Hee-Jung Cho, Sang-Deuk Park, more

Molecular Neurobiology > 2019 > 56 > 5 > 3280-3294

Astrocytes are a unique brain cell-storing glycogen and express lysophosphatidic acid (LPA) receptors. Gintonin is a ginseng-derived exogenous G protein-coupled LPA receptor ligand. Accumulating evidence shows that astrocytes serve as an energy supplier to neurons through astrocytic glycogenolysis under physiological and pathophysiological conditions. However, little is known about the relationships...

article

Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus

Jin Young Bae, Jae Sik Lee, Sang Jin Ko, Yi Sul Cho, more

Brain Structure and Function > 2018 > 223 > 5 > 2259-2268

The neurons in the trigeminal mesencephalic nucleus (Vmes) innervate jaw-closing muscle spindles and periodontal ligaments, and play a crucial role in the regulation of jaw movements. Recently, it was shown that many boutons that form synapses on them are immunopositive for glycine (Gly+), suggesting that these neurons receive glycinergic input. Information about the glycine receptors that mediate...

article

Activated leukocyte cell adhesion molecule is involved in excitatory synaptic transmission and plasticity in the rat spinal dorsal horn

Eun-sung Park, Sang-min Jeon, Haein Weon, Hee-jung Cho, more

Neuroscience Letters > 2017 > 656 > C > 9-14

Activated leukocyte cell adhesion molecule (ALCAM), a member of type I transmembrane immunoglobulin superfamily of cell adhesion molecule, is expressed in the surface membrane of various cell types including neurons. In the spinal cord dorsal horn (DH), the first gate for the sensory and pain transmission to the brain, the expression and function of ALCAM have not been known yet. Therefore, we here...

article

Hepatic ischemia/reperfusion injury disrupts the homeostasis of kidney primary cilia via oxidative stress

Sang Jun Han, Hee-Seong Jang, Sung Young Seu, Hee-Jung Cho, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2017 > 1863 > 7 > 1817-1828

Acute kidney injury (AKI) is a major complication of hepatic surgeries. The primary cilium protrudes to the lumen of kidney tubules and plays an important role in renal functions. Disruption of primary cilia homeostasis is highly associated with human diseases including AKI. Here, we investigated whether transient hepatic ischemia induces length change and deciliation of kidney primary cilia, and...

article

Reversible Induction of Pain Hypersensitivity following Optogenetic Stimulation of Spinal Astrocytes

Youngpyo Nam, Jae-Hong Kim, Jong-Heon Kim, Mithilesh Kumar Jha, more

Cell Reports > 2016 > 17 > 11 > 3049-3061

While glial activation is an integral part of pain pathogenesis, the existence of a causal relationship between glia and pain processing has yet to be demonstrated in vivo. Here, we have investigated whether the activation of spinal astrocytes could directly evoke pain hypersensitivity in vivo via the use of optogenetic techniques. Optogenetic stimulation of channelrhopdopsin-2 (ChR)-expressing spinal...

article

Expression and functional role of metallothioneins I and II in the spinal cord in inflammatory and neuropathic pain models

Aram Kwon, Sang-Min Jeon, Sung-Hun Hwang, Jong-Heon Kim, more

Brain Research > 2013 > 1523 > Complete > 37-48

In this study, the expression and functional role of metallothioneins I and II (MT-I/II) were evaluated in the spinal cord in rat models of inflammatory and neuropathic pain. Complete Freund's adjuvant (CFA) injection into the hindpaw induced an increase in MT-I/II protein expression in bilateral dorsal and ventral horns throughout the spinal cord, while chronic constriction injury (CCI) of the sciatic...

article

N‐3 polyunsaturated fatty acid attenuates cholesterol gallstones by suppressing mucin production with a high cholesterol diet in mice

Ja Kyung Kim, Soo Min Cho, So Hee Kang, Eunjung Kim, more

Journal of Gastroenterology and Hepatology > 27 > 11 > 1745 - 1751

Background and AimThe increasing prevalence of cholesterol gallstone (CG) disease has become an economic burden to the healthcare system. Ursodeoxycholic acid (UDCA) is the only established medical agent used to dissolve gallstones. In investigating novel therapeutics for CG, we assessed the preventive effects of n‐3 polyunsaturated fatty acids (n‐3PUFA) on the formation of CG induced by feeding a...

article

Molecular weight distribution and solution properties of silk fibroins with different dissolution conditions

Hee Jung Cho, Chang Seok Ki, Hanjin Oh, Ki Hoon Lee, more

International Journal of Biological Macromolecules > 2012 > 51 > 3 > 336-341

Four regenerated silk fibroin (SF) samples were prepared under different dissolution conditions and their molecular weight (MW) distributions and solution properties in water and formic acid were examined. SFL, produced by dissolving in LiBr aqueous solution for 6h, showed the highest MW level. In the three SFC samples, produced by dissolving SF in CaCl ₂ /H ₂ O/EtOH solution for dissolution...

article

Determination of the esculetin contents of medicinal plants by liquid chromatography–tandem mass spectrometry

Eun‐Sun Yun, Sung‐Kyu Park, Bog‐Soon Kim, Young‐Zoo Chae, more

Biomedical Chromatography > 26 > 10 > 1247 - 1251

We developed a LC‐MS/MS method for the determination of esculetin contents in medicinal plants. The analysis was performed using multiple reaction monitoring in negative mode, and an XBridge™ C₁₈ column (2.1 × 100 mm, 3.5 µm) was used. Methanol and 0.1% formic acid were used for gradient analysis. The calibration curve showed good linearity (r² > 0.9993). The limits of detection and quantitation...

article

Effect of molecular weight and storage time on the wet- and electro-spinning of regenerated silk fibroin

Hee Jung Cho, Young Jin Yoo, Jong Wook Kim, Young Hwan Park, more

Polymer Degradation and Stability > 2012 > 97 > 6 > 1060-1066

This study examined the effects of the molecular weight (MW) of silk fibroin (SF) and the storage time of dope on the wet- and electro-spinning of regenerated SF. The viscosity of the SF formic acid solution was reduced slightly but constantly just after the dissolution of SF in formic acid. Nevertheless, the wet- and electro-spinnability of SFL and SFC3 did not deteriorate until 3 days storage time...

article

Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity

Sung Hee Hwang, Tae-Joon Shin, Sun-Hye Choi, Hee-Jung Cho, more

Molecules and Cells > 2012 > 33 > 2 > 151-162

Recently, we isolated a subset of glycolipoproteins from Panax ginseng, that we designated gintonin, and demonstrated that it induced [Ca²⁺]_i transients in cells via G-protein-coupled receptor (GPCR) signaling pathway(s). However, active components responsible for Ca²⁺ mobilization and the corresponding receptor(s) were unknown. Active component(s) for [Ca²⁺]_i transients of gintonin were analyzed...

article

Development and validation of a liquid chromatography method with electrospray ionization tandem mass spectrometry for the determination of brotizolam residues in beef and commercial whole milk

Hee‐Jung Cho, Kyul Jo, Hee Yi, Soo Min Cho, more

Biomedical Chromatography > 25 > 9 > 1061 - 1066

In this work, a liquid chromatography–tandem mass spectrometric detection technique was developed and validated for the determination of brotizolam residues in beef muscle and commercial whole milk. This procedure involves the extraction of the analyte from the samples via liquid–solid extraction, and caffeine was used as an internal standard. The analyte was successfully separated on an XTerra‐C₁₈...

article

Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK

Kyung-Min Lee, Sang-Min Jeon, Hee-Jung Cho

European Journal of Pain > 2010 > 14 > 7 > 682.e1-682.e12

Peripheral nerve injury leading to neuropathic pain induces the upregulation of interleukin (IL)-6 and microglial CX3CR1 expression, and activation of p38 mitogen-activated protein kinase (MAPK) in the spinal cord. Here, we investigated whether IL-6 regulates CX3CR1 expression through p38 MAPK activation in the spinal cord in rats with chronic constriction injury (CCI) of the sciatic nerve. Similar...

article

Single‐step extraction followed by LC for determination of (fluoro)quinolone drug residues in muscle, eggs, and milk

Hee‐Jung Cho, Hee Yi, Soo Min Cho, Dong Goo Lee, more

Journal of Separation Science > 33 > 8 > 1034 - 1043

In this study, a simplified method for the extraction and determination of seven fluoroquinolone residues (danofloxacin, difloxacin, enrofloxacin, marbofloxacin, orbifloxacin, ofloxacin, and sarafloxacin) and three quinolones (oxolinic acid, flumequine, and nalidixic acid), in porcine muscle, table eggs, and commercial whole milk, which required no cleanup step, was devised. This procedure involves...

article

Nonlinear toxicokinetics of enrofloxacin in rats

Hee Yi, Myung-Jin Shin, Soo-Min Cho, Dong-Goo Lee, more

Archives of Pharmacal Research > 2010 > 33 > 11 > 1851-1857

The dose-dependent toxicokinetics of enrofloxacin were studied by administering various single subcutaneous doses (5, 10, 20, 40, 70, 100, 150, 200, 300 and 400 mg/kg) in male Sprague-Dawley rats. The blood samples were collected from the tail veins, and the plasma concentration of enrofloxacin was determined by an HPLC-fluorescence detection (FLD) method. The time-concentration profiles of enrofloxacin...

article

Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model

Kyung-Min Lee, Sang-Min Jeon, Hee-Jung Cho

European Journal of Pain > 2009 > 13 > 8 > 794-806

Peripheral nerve injury resulting in neuropathic pain induces the upregulation of interleukin (IL)-6 and tumor necrosis factor-α, which binds to tumor necrosis factor receptor 1 (TNFR1) and induces NF-κB and p38 MAPK activation in the spinal cord and dorsal root ganglia (DRG). We here investigated whether TNFR1 regulates IL-6 expression through NF-κB or p38 MAPK activations in the spinal cord and...

article

S1778 Omega-3 Poly Unsaturated Fatty Acids Attenuated the Formation of Cholesterol Gallstone with High Cholesterol Diet in Mice

Ja Kyung Kim, Soo-Min Cho, Hee Yi, SoHee Kang, more

Gastroenterology > 2009 > 136 > 5 Supplement 1 > A-268

article

Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain

Sang-Min Jeon, Kyung-Min Lee, Hee-Jung Cho

Brain Research > 2009 > 1251 > Complete > 103-111

In this study, we evaluated the expression of MCP-1 in the rat dorsal root ganglion (DRG) and spinal cord following axotomy and chronic constriction injury (CCI) of the sciatic nerve and L5 spinal nerve ligation (L5 SNL) using an immunohistochemical approach. MCP-1 expression in the DRG peaked and declined before the full onset of pain hypersensitivity following nerve injury. Spinal expression of...

article

Characterization of a stem cell population in lung cancer A549 cells

Ji-Min Sung, Hee-Jung Cho, Hee Yi, Chi-Ho Lee, more

Biochemical and Biophysical Research Communications > 2008 > 371 > 1 > 163-167

We isolated a stem cell subpopulation from human lung cancer A549 cells using FACS/Hoechst 33342. This side population (SP), which comprised 24% of the total cell population, totally disappeared after treatment with the selective ABCG 2 inhibitor fumitremorgin C. In a repopulation study, isolated SP and non-SP cells were each able to generate a heterogeneous population of SP and non-SP cells, but...

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INFONA - science communication portal

Search results for: Hee-Jung Cho

Development and validation of a sensitive ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method for quantitative analysis of bambermycin in livestock and aquatic products: Implications for food safety control and regulatory enforcement

Gintonin, a Ginseng-Derived Exogenous Lysophosphatidic Acid Receptor Ligand, Protects Astrocytes from Hypoxic and Re-oxygenation Stresses Through Stimulation of Astrocytic Glycogenolysis

Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus

Activated leukocyte cell adhesion molecule is involved in excitatory synaptic transmission and plasticity in the rat spinal dorsal horn

Hepatic ischemia/reperfusion injury disrupts the homeostasis of kidney primary cilia via oxidative stress

Reversible Induction of Pain Hypersensitivity following Optogenetic Stimulation of Spinal Astrocytes

Expression and functional role of metallothioneins I and II in the spinal cord in inflammatory and neuropathic pain models

N‐3 polyunsaturated fatty acid attenuates cholesterol gallstones by suppressing mucin production with a high cholesterol diet in mice

Molecular weight distribution and solution properties of silk fibroins with different dissolution conditions

Determination of the esculetin contents of medicinal plants by liquid chromatography–tandem mass spectrometry

Effect of molecular weight and storage time on the wet- and electro-spinning of regenerated silk fibroin

Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity

Development and validation of a liquid chromatography method with electrospray ionization tandem mass spectrometry for the determination of brotizolam residues in beef and commercial whole milk

Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK

Single‐step extraction followed by LC for determination of (fluoro)quinolone drug residues in muscle, eggs, and milk

Nonlinear toxicokinetics of enrofloxacin in rats

Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model

S1778 Omega-3 Poly Unsaturated Fatty Acids Attenuated the Formation of Cholesterol Gallstone with High Cholesterol Diet in Mice

Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain

Characterization of a stem cell population in lung cancer A549 cells

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