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Alix and TSG101, known to physically interact with each other, have Pro-rich regions that are bound by ALG-2 Ca 2+ -dependently. We investigated the role of ALG-2 in the Alix-TSG101 association by pulldown assays using Strep-tagged Alix and its various mutants. The ALG-2-binding site was required for the Ca 2+ -dependent pulldown of TSG101 using HEK293T cells, whereas the PSAP sequence,...
ALG-2 belongs to the penta-EF-hand (PEF) protein family and interacts with various intracellular proteins, such as Alix and TSG101, that are involved in endosomal sorting and HIV budding. Through X-ray crystallography, we solved the structures of Ca 2+ -free and -bound forms of N-terminally truncated human ALG-2 (des3-20ALG-2), Zn 2+ -bound form of full-length ALG-2, and the structure...
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