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The abnormal prion protein (scrapie-associated prion protein, PrPSc) is considered to be included in the group of infectious agents of transmissible spongiform encephalopathies. Since PrPSc is highly resistant to normal sterilization procedures, the decontamination of PrPSc is a significant public health issue. In the present study, a hyperthermostable protease, Tk-subtilisin, was used to degrade...
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