Search results for: Marta Scorsetti

Items from 1 to 20 out of 89 results

article

Long term update on toxicity and survival of a phase II trial of linac‐based stereotactic body radiation therapy for low‐intermediate risk prostate cancer

Giuseppe R. D'Agostino, Marco Badalamenti, Sara Stefanini, Davide Baldaccini, more

Background In 2016 we published a phase II study exploring safety and efficacy of Stereotactic Body Radiation Therapy (SBRT) delivered with Volumetric Modulated Arc Therapy (VMAT) and Flattening Filter Free (FFF) beams techniques in prostate cancer (PC) patients. We present herein the updated results on late toxicity and long‐term survival. Methods Patients enrolled in the study had a biopsy‐confirmed...

article

PSMA guided approach for bIoCHEmical relapse after prostatectomy‐ (PSICHE) trial (NCT05022914). Detection rate and treatment decision after 68Ga‐PSMA PET/CT within a prospective study

Giulio Francolini, Marco Banini, Vanessa Di Cataldo, Beatrice Detti, more

The Prostate > 83 > 12 > 1201 - 1206

Background Ultrasensitive imaging has been demonstrated to influence biochemical relapse treatment. PSICHE is a multicentric prospective study, aimed at exploring detection rate with 68Ga‐PSMA‐11 positron emission tomography/computed tomography (PET/CT) and outcomes with a predefined treatment algorithm tailored to the imaging. Methods Patients affected by biochemical recurrence after surgery (prostate...

article

Predictive value of clinical and radiomic features for radiation therapy response in patients with lymph node‐positive head and neck cancer

Ciro Franzese, Sara Lillo, Luca Cozzi, Maria Ausilia Teriaca, more

Head & Neck > 45 > 5 > 1184 - 1193

Background Prediction of survival and radiation therapy response is challenging in head and neck cancer with metastatic lymph nodes (LNs). Here we developed novel radiomics‐ and clinical‐based predictive models. Methods Volumes of interest of LNs were employed for radiomic features extraction. Radiomic and clinical features were investigated for their predictive value relatively to locoregional...

article

Accelerated hypofractionated radiation for elderly or frail patients with a newly diagnosed glioblastoma: A pooled analysis of patient‐level data from 4 prospective trials

Haley K. Perlow, Rahul N. Prasad, Mike Yang, Brett Klamer, more

Cancer > 128 > 12 > 2367 - 2374

Background The standard of care for elderly or frail patients with glioblastoma (GBM) is 40 Gy in 15 fractions of radiotherapy. However, this regimen has a lower biological effective dose (BED) compared with the Stupp regimen of 60 Gy in 30 fractions. It is hypothesized that accelerated hypofractionated radiation of 52.5 Gy in 15 fractions (BED equivalent to Stupp) is safe and efficacious. Methods...

article

Metastatic salivary gland carcinoma: A role for stereotactic body radiation therapy? A study of AIRO‐Head and Neck working group

Ciro Franzese, Rossana Ingargiola, Stefano Tomatis, Nicola Alessandro Iacovelli, more

Oral Diseases > 28 > 2 > 345 - 351

Objectives The role of radiotherapy (RT) for oligometastases is currently established in different oncological settings but data on salivary gland cancer (SGC) are lacking. We evaluated the role of RT in oligometastatic SGC patients, focusing on stereotactic body radiation therapy (SBRT). Materials and methods We performed a retrospective, multicentric study of oligometastatic SGC treated with...

article

Impact of hypofractionated schemes in radiotherapy for locally advanced head and neck cancer patients

Ciro Franzese, Antonella Fogliata, Davide Franceschini, Pierina Navarria, more

The Laryngoscope > 130 > 4 > E163 - E170

Objective To analyze two cohorts of locally advanced head and neck cancer (LAHNC) patients treated with two schedules of hypofractionated radiotherapy and 5 versus 3 mm clinical target volume–planning target volume (CTV‐PTV) margins. Methods 145 patients were included. The patient cohort was divided into two groups. Group A included 97 patients treated with 69.96/54.45 grays (Gy) to the high‐risk...

article

Predictive factors for survival outcomes of oligometastatic prostate cancer patients treated with metastases-directed therapy: a recursive partitioning-based analysis

Ciro Franzese, Lucia Brina, Giuseppe D’Agostino, Davide Franceschini, more

Journal of Cancer Research and Clinical Oncology > 2019 > 145 > 10 > 2469-2479

Purpose The aim of the present study was to provide predictive factors for survival outcomes of oligometastatic prostate cancer (PC) patients treated with stereotactic body radiation therapy (SBRT) as a metastases-directed therapy (MDT). Methods In this cohort study, endpoints included overall survival (OS), progression-free survival (PFS), distant progression-free survival (DFS) and local control...

article

Predicting survival and local control after radiochemotherapy in locally advanced head and neck cancer by means of computed tomography based radiomics

Luca Cozzi, Ciro Franzese, Antonella Fogliata, Davide Franceschini, more

Strahlentherapie und Onkologie > 2019 > 195 > 9 > 805-818

Purpose To appraise the ability of a radiomics signature to predict clinical outcome after definitive radiochemotherapy (RCT) of stage III–IV head and neck cancer. Methods A cohort of 110 patients was included in a retrospective analysis. Radiomics texture features were extracted from the gross tumor volumes contoured on planning computed tomography (CT) images. The cohort of patients was randomly...

article

Postmastectomy radiation therapy using VMAT technique for breast cancer patients with expander reconstruction

Fiorenza De Rose, Antonella Fogliata, Davide Franceschini, Salvatore Cozzi, more

Medical Oncology > 2019 > 36 > 6 > 1-8

Postmastectomy radiotherapy (PMRT) following immediate breast reconstruction is increasingly adopted in the management of breast cancer patients. We retrospectively evaluate the complication rates of PMRT using VMAT technique to immediate tissue expander-based reconstructions and the possible impact of tissue expander volume on radiotherapy planning. We reviewed the data of patients who underwent...

article

Metastasis-directed stereotactic radiotherapy for oligoprogressive castration-resistant prostate cancer: a multicenter study

Luca Triggiani, Rosario Mazzola, Stefano Maria Magrini, Gianluca Ingrosso, more

World Journal of Urology > 2019 > 37 > 12 > 2631-2637

Purpose Herein, we report the clinical outcomes of a multicenter study evaluating the role of SBRT in a cohort of patients affected by oligoprogressive castration-resistant prostate cancer (CRPC). Materials and methods This is a retrospective multicenter observational study including eleven centers. Inclusion criteria of the current study were: (a) Karnofsky performance status > 80, (b) histologically...

article

Radiotherapy for oligometastatic cancer: a survey among radiation oncologists of Lombardy (AIRO-Lombardy), Italy

Barbara Alicja Jereczek-Fossa, Barbara Bortolato, Marianna Alessandra Gerardi, Samantha Dicuonzo, more

La radiologia medica > 2019 > 124 > 4 > 315-322

Aims To evaluate the use of radiotherapy (RT) for oligometastatic cancer (OMC) among radiation oncologists in Lombardy, Italy. Methods and study design A survey with 12 items regarding data of 2016 was sent to all 34 Lombardy RT centers. The survey included six general items and six specific items regarding patient/disease/treatment characteristics. Results Thirteen centers answered the survey...

article

Re-irradiation for recurrent glioma: outcome evaluation, toxicity and prognostic factors assessment. A multicenter study of the Radiation Oncology Italian Association (AIRO)

Pierina Navarria, Giuseppe Minniti, Elena Clerici, Stefano Tomatis, more

Journal of Neuro-Oncology > 2019 > 142 > 1 > 59-67

Introduction The prognosis of glioma is dismal, and almost all patients relapsed. At recurrence time, several treatment options are considered, but to date there is no a standard of care. The Neurooncology Study Group of the Italian Association of Radiation Oncology (AIRO) collected clinical data regarding a large series of recurrent glioma patients who underwent re-irradiation (re-RT) in Italy. ...

article

Phase II trial on SBRT for unresectable liver metastases: long-term outcome and prognostic factors of survival after 5 years of follow-up

Marta Scorsetti, Tiziana Comito, Elena Clerici, Ciro Franzese, more

Radiation Oncology > 2018 > 13 > 1 > 1-10

Background The aim of this study was to evaluate long-term efficacy and survival prognostic factors of stereotactic body radiation therapy (SBRT) for un-resectable liver metastases in patients enrolled in a prospective phase II trial. Methods and materials 5-year local control (LC), overall survival (OS), progression free survival (PFS) and toxicity rates were analyzed in patients with un-resectable...

article

Correction to: ONE SHOT - single shot radiotherapy for localized prostate cancer: study protocol of a single arm, multicenter phase I/II trial

Thomas Zilli, Marta Scorsetti, Daniel Zwahlen, Ciro Franzese, more

Radiation Oncology > 2018 > 13 > 1 > 1-1

Following publication of the original article [1], the authors reported that one of the authors’ names is spelled incorrectly. In this Correction the incorrect and correct author name are shown. The original publication of this article has been corrected.

article

ONE SHOT - single shot radiotherapy for localized prostate cancer: study protocol of a single arm, multicenter phase I/II trial

Thomas Zilli, Marta Scorsetti, Daniel Zwahlen, Ciro Franzese, more

Radiation Oncology > 2018 > 13 > 1 > 1-8

Background Stereotactic body radiotherapy (SBRT) is an emerging treatment alternative for patients with localized prostate cancer. Promising results in terms of disease control and toxicity have been reported with 4 to 5 SBRT fractions. However, question of how far can the number of fractions with SBRT be reduced is a challenging research matter. As already explored by some authors in the context...

article

Proton versus photon deep inspiration breath hold technique in patients with hodgkin lymphoma and mediastinal radiation

Christian Baues, Simone Marnitz, Andreas Engert, Wolfgang Baus, more

Radiation Oncology > 2018 > 13 > 1 > 1-11

Background The benefits of proton therapy in the treatment of patients with Hodgkin lymphoma (HL) are controversially discussed. Therefore we compared intensitiy modulated proton therapy (IMPT) with intensity modulated radiotherapy (IMRT), in the form of volumetric modulated arc therapy (VMAT) in patients with Hodgkin lymphoma (HL), through a comparative treatment planning study. Methods Radiation...

article

Is surgical resection useful in elderly newly diagnosed glioblastoma patients? Outcome evaluation and prognostic factors assessment

Federico Pessina, Pierina Navarria, Luca Cozzi, Roberta Rudà, more

Acta Neurochirurgica > 2018 > 160 > 9 > 1779-1787

ASTRACT Background The incidence of glioblastoma among elderly patients is constantly increasing. The value of radiation therapy and concurrent/adjuvant chemotherapy has been widely assessed. So far, the role of surgery has not been thoroughly investigated. The study aimed to evaluate safety and impact of several entities of surgical resection on outcome of elderly patients with newly diagnosed glioblastoma...

article

Liver metastases from colorectal cancer: propensity score-based comparison of stereotactic body radiation therapy vs. microwave ablation

Ciro Franzese, Tiziana Comito, Elena Clerici, Lucia Brina, more

Journal of Cancer Research and Clinical Oncology > 2018 > 144 > 9 > 1777-1783

Purpose The study aim was to compare the disease control in two groups of patients affected by liver metastases from CRC treated with microwave ablation (MWA) or stereotactic body radiation therapy (SBRT). Methods We extracted data of patients treated between 2009 and 2016. Inclusion criteria were: (1) maximum diameter of the liver lesions less than 4 cm; (2) no more than three liver lesions; (3)...

article

Applying Lean-Six-Sigma Methodology in radiotherapy: Lessons learned by the breast daily repositioning case

Pietro Mancosu, Giorgia Nicolini, Giulia Goretti, Fiorenza De Rose, more

Radiotherapy and Oncology > 2018 > 127 > 2 > 326-331

Lean Six Sigma Methodology (LSSM) was introduced in industry to provide near-perfect services to large processes, by reducing improbable occurrence. LSSM has been applied to redesign the 2D-2D breast repositioning process (Lean) by the retrospective analysis of the database (Six Sigma).Breast patients with daily 2D-2D matching before RT were considered. The five DMAIC (define, measure, analyze, improve,...

article

Critical Appraisal of the Risk of Secondary Cancer Induction From Breast Radiation Therapy With Volumetric Modulated Arc Therapy Relative to 3D Conformal Therapy

Antonella Fogliata, Fiorenza De Rose, Davide Franceschini, Antonella Stravato, more

International Journal of Radiation Oncology*Biology*Physics > 2018 > 100 > 3 > 785-793

To evaluate the excess absolute risk (EAR) comparing volumetric modulated arc therapy (VMAT) and 3-dimensional (3D) conformal radiation therapy (CRT) in breast cancer radiation therapy treatment.Two VMAT arrangements (VMAT_tang and VMAT_full, i.e. partial arcs with and without a sector of 0 Monitor Unit, respectively) and a 3D CRT (field-in-field [FinF]) plan were calculated with an accurate dose...

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INFONA - science communication portal

Search results for: Marta Scorsetti

Long term update on toxicity and survival of a phase II trial of linac‐based stereotactic body radiation therapy for low‐intermediate risk prostate cancer

PSMA guided approach for bIoCHEmical relapse after prostatectomy‐ (PSICHE) trial (NCT05022914). Detection rate and treatment decision after 68Ga‐PSMA PET/CT within a prospective study

Predictive value of clinical and radiomic features for radiation therapy response in patients with lymph node‐positive head and neck cancer

Accelerated hypofractionated radiation for elderly or frail patients with a newly diagnosed glioblastoma: A pooled analysis of patient‐level data from 4 prospective trials

Metastatic salivary gland carcinoma: A role for stereotactic body radiation therapy? A study of AIRO‐Head and Neck working group

Impact of hypofractionated schemes in radiotherapy for locally advanced head and neck cancer patients

Predictive factors for survival outcomes of oligometastatic prostate cancer patients treated with metastases-directed therapy: a recursive partitioning-based analysis

Predicting survival and local control after radiochemotherapy in locally advanced head and neck cancer by means of computed tomography based radiomics

Postmastectomy radiation therapy using VMAT technique for breast cancer patients with expander reconstruction

Metastasis-directed stereotactic radiotherapy for oligoprogressive castration-resistant prostate cancer: a multicenter study

Radiotherapy for oligometastatic cancer: a survey among radiation oncologists of Lombardy (AIRO-Lombardy), Italy

Re-irradiation for recurrent glioma: outcome evaluation, toxicity and prognostic factors assessment. A multicenter study of the Radiation Oncology Italian Association (AIRO)

Phase II trial on SBRT for unresectable liver metastases: long-term outcome and prognostic factors of survival after 5 years of follow-up

Correction to: ONE SHOT - single shot radiotherapy for localized prostate cancer: study protocol of a single arm, multicenter phase I/II trial

ONE SHOT - single shot radiotherapy for localized prostate cancer: study protocol of a single arm, multicenter phase I/II trial

Proton versus photon deep inspiration breath hold technique in patients with hodgkin lymphoma and mediastinal radiation

Is surgical resection useful in elderly newly diagnosed glioblastoma patients? Outcome evaluation and prognostic factors assessment

Liver metastases from colorectal cancer: propensity score-based comparison of stereotactic body radiation therapy vs. microwave ablation

Applying Lean-Six-Sigma Methodology in radiotherapy: Lessons learned by the breast daily repositioning case

Critical Appraisal of the Risk of Secondary Cancer Induction From Breast Radiation Therapy With Volumetric Modulated Arc Therapy Relative to 3D Conformal Therapy

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