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The effects of 3,4-dihydroxyphenylalanine (l-DOPA) on dopamine biosynthesis and cytotoxicity were investigated in PC12 cells. l-DOPA treatment (20–200 μM) increased the levels of dopamine by 226%–504% after 3–6 h of treatment and enhanced the activities of tyrosine hydroxylase (TH) and aromatic l-amino acid decarboxylase (AADC). l-DOPA (20–200 μM) treatment led to a 562%–937% increase in l-DOPA influx...
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