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The Tofts tracer kinetic models are often used to analyze dynamic contrast‐enhanced MRI data. They are derived from a general two‐compartment exchange model (2CXM) but assume negligible plasma mean transit time. The 2CXM estimates tissue plasma perfusion and capillary permeability‐surface area; the Tofts models estimate the transfer constant Ktrans, which reflects a combination of these two parameters...
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