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Background and PurposeSirtuin1 (SIRT1), the founding member of mammalian class III histone deacetylases, is reported to be a drug target involved in fibrotic diseases. However, whether it is an effective drug target in hypertrophic scar treatment is still not known.
Experimental ApproachIn the present study, we observed that SIRT1 localized to both the epidermis and the dermis of skin tissues by...
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