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Tissue inhibitor matrix metalloproteinase‐1 (TIMP1) is one of four identified members of the TIMP family. We evaluated the role of TIMP1 in gastric cancer using human and mouse tissues along with gastric organoids and in vitro cell models. Using quantitative real‐time RT‐PCR, we detected significant overexpression of TIMP1 in the human gastric cancer samples, as compared to normal stomach samples...
Gastric cancer (GC) is a leading cause of cancer‐related deaths worldwide. The Tff1 knockout (KO) mouse model develops gastric lesions that include low‐grade dysplasia (LGD), high‐grade dysplasia (HGD), and adenocarcinomas. In this study, we used Affymetrix microarrays gene expression platforms for analysis of molecular signatures in the mouse stomach [Tff1‐KO (LGD) and Tff1 wild‐type (normal)] and...
BACKGROUNDInfection with Helicobacter pylori, a high‐risk factor for gastric cancer, is frequently associated with chronic inflammation through activation of nuclear factor κB (NF‐κB). Trefoil factor 1 (TFF1) is a constitutively expressed protein in the stomach that has tumor‐suppressor functions and plays a critical role in maintaining mucosal integrity. This study investigated the role of TFF1 in...
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