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Glioma is the most common primary brain tumor in the central nervous system (CNS) with high morbidity and mortality in adults. Although standardized comprehensive therapy has been adapted, the prognosis of glioma patients is still frustrating and thus novel therapeutic strategies are urgently in need. Quercetin (Quer), an important flavonoid compound found in many herbs, is shown to be effective in...
Cancer cells are highly dependent on methionine and cystine (Met–Cys) for survival and proliferation. However, the molecular mechanism is not fully clear. The present study is to investigate the effects of Met–Cys deprivation on glioma cells proliferation. The results showed that Met–Cys double deprivation had synergistic action on elevating ROS level, decreased GSH level and inhibition of glioma...
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