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During the past decade, the outcomes of pediatric patients with acute myeloid leukemia (AML) have plateaued with 5‐year event‐free survival (EFS) and overall survival (OS) of approximately 46 and 64%, respectively. Outcomes are particularly poor for those children with high‐risk disease, who have 5‐year OS of 46%. Substantial survival improvements have been observed for a subset of patients treated...
Background
The optimal number of chemotherapy courses for low‐risk (LR) pediatric acute myeloid leukemia (AML) is not known.
Objective
To compare outcomes for four (21.6 g/m2 cytarabine) versus five (45.6 g/m2 cytarabine) chemotherapy courses for LR‐AML using data from Children's Oncology Group (COG) AAML0531 and AAML1031.
Methods
We compared relapse risk (RR), disease‐free survival (DFS), and...
BACKGROUND
Chemotherapy‐induced nausea and vomiting remain common, distressing side effects of chemotherapy. It has been reported that acupressure prevents chemotherapy‐induced nausea in adults, but it has not been well studied in children.
METHODS
In this multicenter, prospective, randomized, single‐blind, sham‐controlled trial, the authors compared acute‐phase nausea severity in patients ages...
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