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BACKGROUNDANDAIMS: The phenomenon of communication between the nervous and immune systems is commonly accepted. There were postulated several pathways for information exchange between these two systems, among them: neuronal with the vagus nerve, and enzymatic exercised through cyclooxygenases. The fact of biological compensation of many processes in our organisms is well known. In our project we hypothesized...
BACKGROUND AND AIMS: Peripheral administration of gram-negative bacteria endotoxin – lipopolisaccharide (LPS) is known to activate the hypothalamo-pituitary adrenal axis (HPAA) and brain noradrenergic systems. We studied the vagotomized rats responses to peripherally administered LPS using the HPLC-ED to measure the concentration of noradrenaline and their metabolite MHPG in various brain regions...
It is known that obesity is associated with a state of chronic low-level inflammation. Some data indicate that obesity- related stress could increase the hypothalamo-pituitary-adrenal axis activity. This leads to a rise in the plasma glucocorticoid level, which induces the development and differentiation of preadipocytes. Thus, the present study was performed to examine the effect of glucocorticoids...
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