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Poland is a country in Central Europe, bordered by Germany to the west; the Czech and Slovak Republics to the south; Belarus and Ukraine to the east; and Lithuania, Russia, and the Baltic Sea to the north. It is one of the largest countries in Europe covering 312,685 km2. For administration Poland is divided into 16 regions (voivodships), 379 districts (powiaty), and 2,478 local government communes...
Caspase-3 deficiency can limit the efficiency of pro-apoptotic anticancer treatments. Irofulven (hydroxymethylacylfulvene, HMAF, MGI 114, NSC 683863) is an antitumor drug, currently in a Phase III and multiple Phase II trials, which can differentiate between tumor and normal cells in apoptosis induction. This study investigated whether apoptosis induced by irofulven requires caspase-3. Irofulven action...
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