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The interactions between cholecalciferol, a precursor of the active form of Vitamin D 3 , and conventional antiepileptic drugs (valproate, carbamazepine, phenytoin, and phenobarbital) were studied in the maximal electroshock test in mice. Vitamin D 3 applied i.p. at doses of 37.5 and 75 μg/kg, but not at 18.75 μg/kg, significantly raised the electroconvulsive threshold. Furthermore,...
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