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Triblock copolymers of ethylene oxide (EO) and propylene oxide (PO) of EO n/2 PO m EO n/2 type (Pluronics) demonstrate a variety of biological effects that are mainly due to their interaction with cell membranes. Previously, we have shown that Pluronics can bind to artificial lipid membranes and enhance accumulation of the anti-tumor drug doxorubicin (DOX) inside the pH-gradient...
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