The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
We previously reported that platelets from advanced sporadic Alzheimer s disease (AD) patients exhibit two defects: first, an aberrant signal transduction presenting as a thrombin-induced hyperacidification, which is more severe for donors with the apolipoprotein E4 allele (apoE4), and second, an AD-specific Amyloid Precursor Protein (APP) processing defect that presents as retention of APP on the...
Upon activation, platelet α-granules soluble contents are secreted and membrane-bound contents are translocated to the plasma membrane. Membrane-bound proteins include the β-amyloid precursor protein (APP) from which the β-amyloid (Aβ) deposits found surrounding the cerebrovasculature of patients with Alzheimer s Disease (AD) may originate. We show here that activated platelets from AD patients...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.