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Bacterial components have been demonstrated to potently stimulate bone resorption. The mechanisms through which these bacterial components stimulate bone resorption are as yet undefined. We have studied the role of 5-lipoxygenase in lipopolysaccharide-induced bone resorption and contrasted this with that induced by the calcitropic hormones, PTH and 1,25(OH) 2 vitamin D 3 , and the...
Staphylococcus aureus is a Gram-positive bacterium which is associated with bone destruction in conditions such as osteomyelitis. Previous studies have shown that the surface-associated proteins (SAPs) from this organism stimulate bone resorption (S. Nair et al, J. Bone & Mineral Res. 5, 726-734, 1995). The precise mechanisms involved in this process are as yet unknown. One possible way in...
Actinobacillus actinomycetemcomitans is believed to be the causative organism of localised juvenile periodontitis (LJP), a disease in which there is rapid alveolar bone loss leading to the loss of teeth. Previously, we have shown that gentle extraction of this bacterium in saline removes a proteinaceous fraction (termed surface-associated material (SAM)) which contains potent bone resorbing activity...
In this study we tested the hypothesis that exercise induces an adaptive response in the developing skeleton which may be monitored in vivo by measuring biochemical markers of bone metabolism. The effects of exercise on two biochemical markers of bone formation were determined; the carboxy-terminal propeptide of type I procollagen (PICP), and the bone-specific isoenzyme of alkaline phosphatase (BAP),...
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