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BACKGROUND
The best treatment for patients with advanced non–small cell lung cancer (NSCLC) and a poor performance status is not well defined. In this phase 2 trial, patients were randomized to receive treatment with either single‐agent pemetrexed or 1 of 2 combination regimens.
METHODS
Patients with newly diagnosed, histologically confirmed nonsquamous NSCLC and an Eastern Cooperative Oncology...
BACKGROUND
Chemotherapy‐induced nausea and vomiting remain common, distressing side effects of chemotherapy. It has been reported that acupressure prevents chemotherapy‐induced nausea in adults, but it has not been well studied in children.
METHODS
In this multicenter, prospective, randomized, single‐blind, sham‐controlled trial, the authors compared acute‐phase nausea severity in patients ages...
BACKGROUND
There is no clear consensus between pediatric and adult providers about the treatment of adolescents and young adults (AYAs) with Hodgkin lymphoma (HL).
METHODS
Failure‐free survival (FFS) and overall survival (OS) were compared between 114 patients ages 17 to 21 years with HL who were treated on the Eastern Cooperative Oncology Group‐American College of Radiology Imaging Network Intergroup...
BACKGROUND
Children with cancer in high‐income and low‐income countries often use traditional complementary/alternative medicine (TCAM). With efforts by the World Health Organization and international twinning programs improving access to conventional care for patients with childhood cancer, understanding the global use of TCAM is important because reliance on TCAM may affect time to presentation,...
BACKGROUNDIn their previous analysis of papillary thyroid carcinomas (PTCs) from an Ukrainian‐American cohort that was exposed to iodine‐131 (131I) from the Chernobyl accident, the authors identified RET/PTC rearrangements and other driver mutations in 60% of tumors.
METHODSIn this study, the remaining mutation‐negative tumors from that cohort were analyzed using RNA sequencing (RNA‐Seq) and reverse...
BACKGROUNDDoxorubicin is associated with progressive cardiac dysfunction, possibly through the formation of doxorubicin‐iron complexes leading to free‐radical injury. The authors determined the frequency of hemochromatosis (HFE) gene mutations associated with hereditary hemochromatosis and their relationship with doxorubicin‐associated cardiotoxicity in survivors of childhood high‐risk acute lymphoblastic...
BACKGROUND:The authors evaluated a 3‐week schedule of bevacizumab in patients with recurrent high‐grade glioma (HGG).
METHODS:Patients received bevacizumab 15 mg/kg every 3 weeks and were evaluated every 6 weeks until tumor progression. Tissue correlates were used to quantify tumor content of vascular endothelial growth factor A (VEGFA) and vascular endothelial growth factor receptor‐2 (VEGFR2)....
BACKGROUND:Oncotype DX breast cancer assay (Genomic Health, Redwood City, Calif) stratifies patients with early breast cancer according to risk of distant recurrence. The authors hypothesized that the test is ordered when clinicopathological variables yield equivocal risk estimates. The current study also showed how often the test clarifies clinically ambiguous risk status.
METHODS:The authors examined...
BACKGROUND:Despite limited preclinical and clinical investigations, milk thistle (MT) is often used for the treatment of chemotherapy‐associated hepatotoxicity. Limited treatment options exist for chemotherapy‐related hepatoxicity. Given the wide use of MT, the authors investigated MT in both the laboratory and a clinical setting.
METHODS:In a double‐blind study, children with acute lymphoblastic...
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