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Surface charge on insulator polymers in breakers, gas insulated switchgears and other electrical apparatuses, plays a dominant role in the insulation performance of power system. Meanwhile, the surface potential on the functional dielectric can be one of the criteria in the evaluation of the charge storage performance when the dipoles formed in polymer are taken into consideration during corona poling...
To investigate complex electrophysiological behaviour (such as reentrant cardiac arrhythmias) in the setting of the complex anatomy of the heart, the use of a simplified model is computationally more effective. In this study, the Rogers-modified FitzHugh-Nagumo model was further modified to allow control of action potential upstroke velocity, conduction velocity, action potential duration and refractory...
The E1784K mutation in SCN5A was reported as a phenotypic overlap between the Type 3 Long QT syndrome (LQT3) and the Brugada syndrome (BrS). However it is still unclear if the E1784K mutation-induced changes at ionic channel level is sufficient to account for the two phenotypic and how they affect ventricular excitation waves at tissue level. In this study, we used a biophysically detailed computer...
Cardiac rhythm is irregular with heart rate varies from time to time. Heart rate variation (HRV) is clinically relevant and indicative of a pathological condition. However, the mechanisms underlying the HRV are still controversial and stochastic nervous modulation may be a major responsible factor. In this study, we implemented a computer simulation study to investigate a causative link between stochastic...
Slow conduction through the Purkinje-ventricular junction (PVJ) is thought to result in conduction block and ultimately re-entry under certain pathological conditions. The relationships between tissue structure, conduction velocity and the safety of conduction at such junctions however, are unknown. We developed an electrophysiologically detailed 3D model of the PVJ and varied the Purkinje fibre thickness...
Atrial fibrillation (AF) is commonly associated with rapid excitation of the atria, but mechanisms of its initiation are unknown. Intracellular Ca2+ dynamics has been shown to affect cell restitution properties and, as a result, patterns of rapid reentrant excitation in ventricles at early stages of ventricular fibrillation. We study effects of the intracellular Ca2+ concentration changes on restitution...
Remarkable differences in action potential properties between the Purkinje fibre and ventricular cells may lead to abnormalities in excitation conduction through the Purkinje-ventricular junction (PVJ) and arrhythmogenic behaviour. We develop a family of electrophysiologically detailed computer models for rabbit epicardial, midmyocardial and endocardial ventricular myocytes, as well as the rabbit...
In both human and animal mammals, the pacemaker of the heart, the sinoatrial node (SA node), deteriorates with age. The main features of the aged SA nodes are a slow pacemaking rate and possible SA node-atrium conduction exit block or arrest of SA node pacemaking (i.e., termination of the SA node pacemaker activity). The mechanisms underlying the age-related dysfunction of the heart are unclear. In...
The electrocardiogram (ECG) is an important index of clinical diagnosis of cardiac arrhythmias. Simulations of ECG had revealed the causative relationship between waveforms of ECG and action potentials (APs). However, those studies were mainly based on the Luo-Rudy (LRd) model or the Priebe-Beuckelman (PB) model. In this study, we developed a ID model of transmural ventricular strand based on the...
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