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We have used cannabinoid CB 1 knock-out mice in a two-trial object recognition test to assess the role of cannabinoid CB 1 receptors in memory. Cannabinoid CB 1 knock-out mice are able to retain memory for at least 48 h after the first trial whereas the wild-type controls lose their capacity to retain memory after 24 h. These results suggest that endogenous cannabinoid CB ...
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