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The brain develops and grows within a well-controlled internal environment that is provided by cellular exchange mechanisms in the interfaces between blood, cerebrospinal fluid and brain. These are generally referred to by the term “brain barriers”: blood–brain barrier across the cerebral endothelial cells and blood–CSF barrier across the choroid plexus epithelial cells. An essential component of...
Proteins of the ATP-binding cassette (ABC) family, present at the blood–brain barrier interfaces, have been shown to reduce the entry of compounds from blood into the brain by active efflux. Their substrates are diverse including many drugs and toxins and therefore provide an important mechanism for brain neuroprotection. However, knowledge of their presence and function in the developing brain is...
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