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The function of the cellular prion protein (PrP C ) in healthy brains remains poorly understood, in part because Prnp knockout mice are viable. On the other hand, transient knockdown of Prnp homologs in zebrafish (including two paralogs, prp1 and prp2) has suggested that PrP C is required for CNS development, cell adhesion, and neuroprotection. It has been argued that zebrafish Prp2...
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