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Thiomarinol and mupirocin are assembled on similar polyketide/fatty acid backbones and exhibit potent antibiotic activity against methicillin‐resistant Staphylococcus aureus (MRSA). They both contain a tetrasubstituted tetrahydropyran (THP) ring that is essential for biological activity. Mupirocin is a mixture of pseudomonic acids (PAs). Isolation of the novel compound mupirocin P, which contains...
Die Umwandlung …… des biosynthetischen Intermediats Pseudomonsäure B in Pseudomonsäure A, die mit dem formalen Verlust einer Hydroxygruppe einhergeht, ist notwendig, um dessen antibiotisches Potential vollständig auszuschöpfen. In der Zuschrift auf S. 3988 ff. beschreiben T. J. Simpson, C. L. Willis et al. die komplette Sequenz der beteiligten Intermediate und die Identifizierung der assoziierten...
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