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Mitochondria have been suggested as a potential target for cytoprotective strategies. It has been shown that increased K+ uptake mediate by mitochondrial ATP-regulated potassium channels (mitoKATP channel) or large-conductance Ca2+-activated potassium channels (mitoBKCa channel) may provide protection in different models of cell death. Since recent findings demonstrated the presence of BKCa channels...
Potassium channels have been found in the inner mitochondrial membranes of various cells. The activation of these channels is cytoprotective. Hence, the identification of ion channels present in the inner mitochondrial membrane of skin cells is important in distinguishing possible protective mechanisms. In our study, inner membrane mitochondrial channels of the keratinocyte and fibroblast were investigated...
Transient cerebral ischemia is known to induce endogenous adaptive mechanisms such as the activation of mitochondrial ATP regulated or Ca2+ regulated large conductance potassium channels that can prevent or delay neuronal injury. However, molecular mechanism of this effect remains unclear. In this study, a single channel activity was measured with patch-clamp of the mitoplasts isolated from gerbil...
Transient cerebral ischemia is known to induce endogenous adaptive mechanisms such as the activation of mitochondrial ATP-sensitive potassium channels or calcium-sensitive largeconductance potassium channels that can prevent or delay neuronal injury. In this study a single channel activity was measured after patch-clamp of the mitoplasts isolated from control gerbil hippocampus. In 70% of the all...
Ion channels are present in the inner mitochondrial membrane. They play an important role in cellular processes. Potassium and chloride channels are involved in regulation of mitochondrial volume, membrane potential and acidification. The mitochondrial potassium channels have been suggested as triggers and end effectors in cytoprotection. In our study we measured single channel activities after reconstitution...
Ion channels are present in the inner mitochondrial membrane. They play an important role in cellular processes. Potassium and chloride channels are involved in regulation of mitochondrial volume, membrane potential and acidification. The mitochondrial potassium channels have been suggested as triggers and end effectors in cytoprotection. In our study we measured single channel activities after reconstitution...
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