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Spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) appears to play an important role in cardiac sinoatrial node pacemaking. However, comparatively little is known about the role of intracellular Ca2+ in the atrioventricular node (AVN). Intracellular Ca2+ was therefore monitored in cells isolated from the rabbit AVN, using fluo-3 in conjunction with confocal microscopy. These cells displayed...
Ca 2+ sparks, the elementary units of sarcoplasmic reticulum (SR) Ca 2+ release in cardiac, smooth and skeletal muscle are localized (2-4 μm) increases in intracellular Ca 2+ concentration, [Ca 2+ ] i , that last briefly (30-100 ms). These Ca 2+ , sparks arise from the openings of a single SR Ca 2+ release channel...
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