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We propose a novel framework for longitudinal registration which can handle large intra-subject anatomical variations. The framework exploits freely available spatio-temporal atlases, which can aid the longitudinal registration process as it provides prior information about the missing anatomical evolution between two scans taken over large time-interval. The spatio-temporal atlas is used to develop...
The aim of this study is to develop a MR compatible PET that is insertable to MRI and allows simultaneous PET and MR imaging of human brain. The brain PET having 72 detector modules arranged in a ring of 330 mm diameter was designed. Each PET module composed of 4 ? 4 matrix of 3 mm ? 3 mm ? 20 mm LYSO crystals coupled to a tileable 4 ? 4 array Geigermode avalanche photodiode (GAPD) and designed to...
Vascular disrupting agents are anticancer agents that typically produce a cytostatic tumor response. Vessel size index magnetic resonance imaging (MRI) allows for the estimation of the fractional blood volume (fBV) and blood vessel size (Rv). We assessed whether the vessel size index parameters provided imaging biomarkers for detecting early tumor response to a vascular disrupting agent.GH3 prolactinomas...
[Gd(TTDA-BOM)]2- is a newly developed paramagnetic contrast agent. The ligand, TTDA-BOM, bears a benzyloxymethyl group so that the lipophilicity is increased. The water exchange rate for [Gd(TTDA-BOM)]2- is significantly higher than that of [Gd(DTPA)]2- and [Gd(BOPTA)]2-. In addition, the bound relaxivity of this Gd (III) complex has a remarkably high value with HSA. Therefore, it has potential to...
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