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Luliberin (luteinizing hormone releasing-hormone, LHRH) is the key regulatory decapeptide that controls reproduction in mammals. It is secreted by the hypothalamus and after binding to a specific receptor it initiates a series of events leading to the liberation of lutropin (LH) and finally steroid sex hormones. In some case, the infertility in females and males may be explained by mutations of the...
Luliberyn plays a pivotal role in the reproductive system. Its analogs have wide therapeutic applications ranging form the treatment of some human cancers, gynecological and sexually transmitted diseases to animal breeding. In the article, the development of luliberin agonists and antagonists and the principles of their application were briefly reviewed. Sequences of some important natural and synthetic...
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