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Background
Prior studies have shown the presence of immunohistochemical staining for the SARS‐CoV‐2 spike protein (SP) in endothelial cells and eccrine epithelium of acral perniosis classified as “COVID toes.” Yet, other studies have been unable to detect SARS‐CoV‐2 RNA in skin biopsies of “COVID toes” by reverse‐transcriptase polymerase chain reaction testing.
Objective
In order to address these...
Background
Acral inflammatory lesions that have some resemblance to idiopathic or autoimmune‐associated perniosis (chilblains) have been described in multiple countries during the COVID‐19 pandemic.
Methods
We examined histopathologic findings in six consecutive such cases from five patients received in mid‐May to mid‐June of 2020, evaluating immunohistochemical staining for the SARS‐CoV‐2 nucleocapsid...
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