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The characteristics and functions of CD4+CD25+ regulatory T cells (Tregs) have been well defined in murine and human systems. However, the interaction or crosstalk between CD4+CD25+ Tregs and dendritic cells (DCs) remains controversial. In this study, the effects of chronic hepatitis B (CHB) CD4+CD25+ Tregs on the maturation and function of monocyte‐derived DCs were examined. The results showed that...
Summary. Telbivudine is an orally bioavailable L‐nucleoside with potent and specific anti‐hepatitis B virus activity. The higher rate of hepatitis B e antigen (HBeAg) seroconversion during telbivudine treatment than other potent anti‐HBV agents suggests a potential immunomodulatory effect. We sought to determine the effects of telbivudine on the immune system, particularly on cytokine production...
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