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Administration intraperitoneally of the Ascaris α-chymotrypsin inhibitor (40-300 mg/kg/day.) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. The low doses of α-chymotrypsin inhibitor (40-80 mg/kg/day) significantly decreased the number of live fetuses per litter, increased the number of fetal resorptions. The symptoms of matemal toxicity that occurred...
It has been found that alpha-chymotrypsin inhibitor isolated from Ascaris lumbricoides suum acts embryotoxically on the Leghorn chicken embryo. An increase in embryo mortality with increasing dose of the inhibitor has been observed after its administration into the yolk sac on day 4, 8 or 13 of incubation. There is a linear interrelationship between the logarithm of the dose of alpha-chymotrypsin...
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