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Lactoferrin is an iron-binding glycoprotein which has been shown to be overexpressed in human endometrial carcinomas. The lactoferrin gene in the mouse is directly regulated by estradiol. Sequence data suggests that human lactoferrin gene contains an estrogen response element (ERE). There is very little data available regarding control of lactoferrin expression in human endometrium. The purpose...
Our recent studies indicated that an inhibition of nitric oxide (NO) synthesis increased the infection rate in the urinary tract of nonpregnant animals. In view of considerable association between urogenital infection, intrauterine growth retardation, and preterm labor, we investigated the role of NO as a modifier of host-infection relationship during pregnancy. We examined whether combined effects...
Decay Accelerating Factor (DAF) is a GPI-anchored membrane protein that protects host tissues from complement mediated damage. DAF regulates complement activation at the critical C3 convertase step by preventing the association or by dissociating the two components on the enzyme. We have recently observed that DAF is up-regulated during the secretory phase of the normal menstrual cycle, (SGI 1994)...
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