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Objective: To examine the effects of epidermal growth factor (EGF), transforming growth factor-β (TGF-β), and fibroblast growth factor (FGF) on insulin-like growth factor binding protein (IGFBP) secretion by cultured human granulosa-luteal cells.Design: Granulosa-luteal cells obtained at the time of oocyte harvest for IVF were cultured in serum-free medium in the presence or absence of EGF, TGF-β,...
Objective: To determine insulin-like growth factor (IGF)-I and IGF-II levels, IGF binding protein (IGFBP) profile, and IGFBP-4 protease activity in androgen-dominant follicular fluid (FF) from female-to-male trans-sexuals and to compare with those in follicles from normocycling women.Design: Follicular fluid samples were obtained from four female-to-male trans-sexuals and 15 women with normo-ovulatory...
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