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This presentation reviews the different nail cosmetics as well as their possible side effects.Common complications of manicuring include acute and chronic paronychia, nail plate surface abnormalities and onycholysis. These, however, are usually due to mechanical trauma caused by instruments rather than to the cosmetics utilized for manicuring.Nail enamel may cause nail plate pigmentation and occasionally...
Although Fusarium sp. are widely present in the soil, toenail invasion by Fusarium oxysporum is quite uncommon. In immunosuppressed patients, onychomycosis due to Fusarium sp. may be dangerous since it can be a possible portal of entry for a systemic infection.The clinical appearance of Fusarium onychomycosis is typical and consists of acute paronychia associated with proximal or total leukonychia...
Mastocytosis is characterized by an increased proliferation of mastcells. The pathogenesis is still only poorly understood. Both cytokines inducing mast cell proliferation and changes in the c-kit receptor appear to be involved. The mast cell leukemia cell line HMC-1 is characterized by ligand independent growth due to point mutations of the c-kit gene at codons 560 and 816. Recent findings suggest...
Unusual types of onychomycosis may be observed in HIV patients.These include proximal subungual onychomycosis due to Trichophyton rubrum, onychomycosis due to Fusarium sp. and onychomycosis due to Candida sp.In the last 3 years, we diagnosed proximal subungual onychomycosis due to Trichophyton rubrum in 25 patients. 22 of these 25 patients were affected by AIDS and had developed their nail lesions...
Itraconazole is an orally active antifungal which combines a broad spectrum of activity with a low incidence of minor and major adverse reactions.Itraconazole activity against Candida species makes it a most useful drug in various forms of candidosis including recalcitrantCandida infections associated with Chronic mucocutaneous candidiasis.We report here 2 children affected by Chronic mucocutaneous...
The aim of our study was to compare different Dermatophagoides allergenic materials and to correlate the presence of serum Dermatophagoides IgE to aeroallergen patch test results. The following allergenic materials:- Dermatophagoides pteronyssinus (DPT) lyophilized alpha fraction in buffered saline/glycerol 50% and/or in petrolatum (Bayropharm-DHS);50% DPT and 50% Dermatophagoides farinae (DF) whole...
Type I hypersensitivity reactions are involved in a number of allergic dermatological diseases which appear to be increasing in the past decades. Major advances have recently been made which may help to decrease or reverse this trend and which may provide new tools to better treat the afflicted patients. Like with all specific immune reactions, antigen recognition by immunocompetent dendritic cells...
Chronic urticaria is mostly idiopathic, the remainder being caused by allergens, pseudoallergens and physical agents. In order to clarify the cause of idiopathic chronic urticaria, 67 hospitalized patients with treatment-resistant, severe disease were placed on a low-additive diet, in a prospective, stringently controlled study. In 73% of the patients, symptoms ceased or were markedly reduced within...
Nail abnormalities are frequently observed in patients with significant neurologic deficit of the limbs. These include patients with peripheral neuropathies and patients with sensory or motor limb defects due to central nervous system diseases.In peripheral neuropathies nail changes are secondary to impaired digital perfusion caused by autonomic fibers involvement. When ischaemia is mild and intermittent...
In the last few years intermittent drug administration has been proposed for the treatment of onychomycosis with the triazole derivative Itraconazole. The aim of this study was to verify whether intermittent therapy with Terbinafine is effective in the treatment of Dermatophyte onychomycosis and to compare the results of intermittent Terbinafine with those of intermittent Itraconazole and continuous...
Mast cell proliferative disease of childhood can present as solitary or multiple mastocytomas, as urticaria pigmentosa or as systemic mastocytosis. The disease is almost invariably benign, with spontaneous remission by puberty. This fits with the phenotype of lesional cells which resemble mature skin mast cells in that they are c-kit, Fc RI, tryptase and chymase positive and Ki 67 negative. Expression...
Ingrown nails, which more commonly affect the great toes of young adults, are a common complaint. Hyperhidrosis, congenital malalignment, improper cutting of toenails as well as unsatisfactory footwear all contribute to the development of this painful condition. The condition starts when spicules breaking off from the lateral edge of the nail plate penetrate into the tissues of lateral nail fold...
Antibody-dependent effector mechanisms usually provide protection against infectious agents. Immune complexes occur physiologically in the circulation and are not necessarily associated with immuno-pathological effects. Whenever an antibody binds to its specific antigen, immune complexes are formed. These same mechanisms are, however, responsible for disease development when they evolve in an uncontrolled...
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