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INTRODUCTION: Subthalamic nucleus deep brain stimulation (STN-DBS) is most effective treatment for Parkinson’s disease (PD) motor symptoms. A number of epidemiological studies have recently highlighted the association between hemoglobin (HGB) levels and PD risk. Interestingly, several lines of evidence confirm that STN-DBS increases regional cerebral blood flow and oxygen concentrations in target...
INTRODUCTION: Two notable targets of the pedunculopontine tegmental nucleus (PPN) circuitry, the substantia nigra (SN) and the ventral tegmental area (VTA), are implicated in locomotion and reward processing. A dysfunction of these regions occurs in Parkinson’s and related disorders as well as in various psychiatric conditions, and over the course of normal aging AIM(S): In the present study, we were...
INTRODUCTION: Loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) lead to motor deficits observed in patients with Parkinson’s disease (PD). The neurosurgical therapy of choice is high frequency stimulation of subthalamic nucleus (HFS-STN) improved motor control. The motor impairment depends on the progression of nigral degeneration and in rats model of PD may be measured by Vermicelli...
BACKGROUND AND AIMS: The limbic glutamatergic neurotransmission may be involved in the biological mechanisms underlying anxiety-related disorders. The purpose of the present study was to determine the influence of NMDA glutamatergic receptor antagonist – D-AP7 infusions into the medial septum (MS) on time spent in open arms in rats differing in behavioral characteristics, stress susceptibility and...
BACKGROUND AND AIMS: The subthalamic nucleus (STN) is the best target for deep brain stimulation (DBS) elevating motor symptoms in Parkinson’s disease (PD) patients. Although DBS is beneficial for patients with PD, it can also cause psychiatric and autonomic side effects of unknown etiology. Since the depression-like behavior is described after high frequency subthalamic stimulation (HFS-STN) in rats,...
BACKGROUND AND AIMS: The activity of serotonin (5-HT) in the brain is strictly connected with the raphe nuclei. They are connected mainly with and influence the prefrontal cortex and limbic structures. Clinical studies indicate that 30% of people with autism spectrum disorder (ASD) have elevated platelet 5-HT level. The aim of the study was to investigate whether chronic (16-days) electrical stimulation...
BACKGROUND AND AIMS: Food intake is regulated not only by homeostatic requirements but also by emotional factors. The nucleus accumbens, particularly its shell region (AcbSh) is a part of the mesolimbic dopaminergic system which is responsible for a positive emotional aspect of various homeostasis-relevant stimuli. In the present work, we tested the AcbSh involvement in feeding behavior using an experimental...
BACKGROUND AND AIMS: Dopamine projections from the ventral tegmental area (VTA) – a somatodendritic region of mesolimbic system to the nucleus accumbens (particularly its shell region, AcbSh) – which constitutes its main terminal structure may play a central role in modulating affective states. In the present work, we used model of the VTA electrical stimulation-induced feeding reaction to research...
The central nucleus of the amygdala (CeA) is involved in fear conditioning and participates in euroendocrine response to stressful stimuli. In our previous study, we found that CeA also influences immune function, especially innate antitumore response. In the present study, we investigated the influence of 14-day electrical stimulation of the CeA on corticosterone level (CORT; determined by radioimmunoassay)...
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