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Understanding the targeted cellular uptake of nanomaterials is an essential step to engineer and program functional and effective biomedical devices. In this respect, the targeting and ultrafast uptake of zeolite nanocrystals functionalized with Cetuximab antibodies (Ctxb) by cells overexpressing the epidermal growth factor receptor are described here. Biochemical assays show that the cellular uptake...
On page 5431, L. De Cola, D. Bonifazi, and co‐workers report the fast targeting and cancer cells uptake of nanozeolite/Cetuximab bioconjugates. The effects are depicted on the front cover, which highlights the antibody‐dependent and receptor‐mediated endocytosis of this luminescent nanomaterial by the cancer cells. This hasty internalization profile can be exploited to reduce the nanomaterial clearance...
L. De Cola and co‐workers report a nanocomposite hydrogel able to induce in vitro chemotaxis of stem cells on page 4881. The cover image shows a nanocomposite hydrogel containing mesoporous silica nanoparticles integrated into the polymeric network. The controlled release of SDF‐1α from the hydrogel induced the chemotaxis of stem cells, while the optimal mechanical properties enhanced stem cells proliferation...
The challenge of mimicking the extracellular matrix with artificial scaffolds that are able to reduce immunoresponse is still unmet. Recent findings have shown that mesenchymal stem cells (MSC) infiltrating into the implanted scaffold have effects on the implant integration by improving the healing process. Toward this aim, a novel polyamidoamine‐based nanocomposite hydrogel is synthesized, cross‐linked...
The development of ordered graphene‐based materials combining high stability, large surface areas, ability to act as absorbent of relevant chemical species, and solution processability is of significance for energy applications. A poorly explored approach relies on the controlled nanostructuration of graphene into robust and highly ordered 3D networks as a route to further leverage the exceptional...
On page 1044, P. Samorì and co‐workers present the preparation of graphene‐based 3D covalent networks (G3DCNs) with tunable interlayer distances. The G3DCNs are prepared via controlled polymerization of benzidines with graphene oxide at different reaction temperatures under catalyst‐ and template‐free conditions. High‐performance supercapacitors are also achieved using the reduced form of G3DCNs as...
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