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Aims/hypothesis Activin receptor-like kinase 7 (ALK7), a member of the type I receptor serine/threonine kinases of the TGF-β superfamily, was recently reported to regulate cell proliferation and apoptosis. We hypothesised that ALK7 may play a role in modulating pancreatic beta cell proliferation and/or apoptosis. Methods We detected ALK7 expression in beta cells using RT-PCR, immunostaining and...
Aims/hypothesis The role of gamma-aminobutyric acid (GABA) and A-type GABA receptors (GABAARs) in modulating islet endocrine function has been actively investigated since the identification of GABA and GABAARs in the pancreatic islets. However, the reported effects of GABAAR activation on insulin secretion from islet beta cells have been controversial. Methods This study examined the hypothesis...
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