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Using an isotope labelling technique it has been shown that an organophosphorus insecticide methylparathion (0,0-diethyl 0-4-nitrophenyl phosphorothioate) depressed calcium uptake by sarcoplasmic reticulum isolated from rabbit hind leg muscle. The effect was significant for insecticide concentrations of 50 and 100 µM and was dose-dependent The insecticide exerted a more pronounced effect on calcium...
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