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Super-resolution microscopy such as STED [1, 2], SSIM [3], or PALM/STORM [4] placed their respective critical requirements on the fluorescent labeling, thereby limits their applications in biology. Polarization as the fourth dimension of fluorescence can also provide intensity modulation, yet without the restriction to specific fluorophores. Here we present a new technique termed super-resolution...
Aberrant DNA methylation has long been implicated in cancers. In this letter, we present a highly discriminative DNA methylation biomarker for non-small cell lung cancers (NSCLCs) and 14 other cancers. Based on 69 NSCLC cell lines and 257 cancer-free lung tissues, we identified a CpG island in SCT gene promoter, which was verified by qMSP experiment in 15 NSCLC cell lines and three immortalized human...
Background Accumulated to-date microarray data on ischemia reperfusion injury (IRI) of kidney represent a powerful source for identifying new targets and mechanisms of kidney IRI. In this study, we conducted a meta-analysis of gene expression profiles of kidney IRI in human, pig, rat, and mouse models, using a new scoring method to correct for the bias of overrepresented species. The gene expression...
We present a computational method that combines genome-wide DNA methylation and copy number variation data in an integrated fashion with the aim of finding mechanistic associations between genome instability and local DNA methylation changes. The method is applied to Luminal A breast cancer early-stage tumour samples and focuses on methylation events occurring at frequently rearranged genome locations...
We present polyadq, a program for detection of human polyadenylation signals. To avoid training on possibly flawed data, the development of polyadq began with a de novo characterization of human mRNA 3' processing signals. This information was used in training two quadratic discriminant functions that polyadq uses to evaluate potential polyA signals. In our tests, polyadq predicts polyA signals with...
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