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Neurotransmitter secretion at synapses is controlled by several processes—morphological docking of vesicles at release sites, priming of docked vesicles to make them fusion competent, and calcium-dependent fusion of vesicles with the plasma membrane [1, 2]. In worms, flies, and mice, mutants lacking UNC-13 have defects in vesicle priming [3–5]. Current models propose that UNC-13 primes vesicles by...
The anaphase-promoting complex (APC) is a multisubunit E3 ubiquitin ligase that targets key cell cycle regulatory proteins for degradation. Blockade of APC activity causes mitotic arrest [1, 2]. Recent evidence suggests that the APC may have roles outside the cell cycle [3–6]. Several studies indicate that ubiquitin plays an important role in regulating synaptic strength [7–13]. We previously showed...
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