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The common abuse of antibiotics during the twentieth century caused the development of many multiresistant pathogens to classic antibiotics. To find new strategies to fight against resistant pathogens is the challenge of the twenty-first century. Since they seem to be natural antibiotics, peptides produced by bacteria, insects, amphibians and mammals with cytotoxic activities against bacteria, mycobacteria,...
By now, over 800 different antimicrobial peptides have been identified in fauna and flora. Antimicrobial peptides (AMPs) are an important part of the innate immunity of all living organisms. The first animal AMP was found in 1962 by Kiss and Michl in the venomous skin secretion of the orange speckled frog Bombina variegata. Most known AMPs are multifunctional as effectors of innate immunity and have...
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