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Our recent study has indicated that a moderate lesion induced by bilateral 6-hydroxydopamine (6-OHDA) injections into the ventrolateral region of the caudate-putamen (CP) in rats, modeling preclinical stages of Parkinson’s disease, induces a “depressive-like” behavior which is reversed by chronic treatment with pramipexole (PRA).The aim of the present study was to examine the influence of the above...
Postmortem studies of depressed patients showed that one of the most consistent findings is a decrease in the density of glial cells in human brain cortical regions, especially in the prefrontal and cingular areas. Furthermore, a decline in the number of astrocytes in the prefrontal cortex was found in rats after chronic unpredictable stress – one of the generally accepted animal models of depression...
Neuropeptide Y (NPY) is a 36-amino acid neurotransmitter and neuromodulator widely distributed in the mammalian central and peripheral nervous system and has been associated with a number of physiological and pathological conditions. In the forebrain this peptide is preferentially expressed in interneurons and modulates, mainly inhibits, the release of other neurotransmitters. NPY acts on specific...
Oxygen-glucose deprivation (OGD) induces excitotoxic cell death mediated primarily by excessive release of glutamate. A growing body of evidence suggests that metabotropic glutamate (mGlu) receptors can modulate glutamatergic transmission, so these receptors are regarded as potential targets for neuroprotective drugs. Group III mGluRs (mGlu4, mGlu6, mGlu7 and mGlu8) agonists are known to reduce glutamatergic...
Neuropeptide Y (NPY), a 36 amino acid peptide widely distributed in the nervous system, inhibits glutamatergic transmission and decreases hippocampal epileptiform activity which may lead to neuroprotection. Such effects were observed in some earlier studies, but results are divergent and the role of particular Y receptors remains unclear. In the present study we investigated a possibility of neuroprotective...
Our recent data have shown that systemic infl ammation evoked by lipopolysaccharide (LPS) stimulates NO-mediated signalling pathways in the midbrain. The aim of the present study was to investigate the dynamics of proinfl ammatory genes expression in mouse hippocampus during 4 days after intraperitoneal injection of LPS (1 mg/kg b.w.). Moreover, the selected biochemical processes involved in cell...
Neuropeptide Y (NPY), a 36 amino acid neurotransmitter, is involved in the regulation of emotional behavior and its role in the central responses to peripheral immune challenge is postulated. Plasma NPY levels rises in human sepsis and NPY improved survival in the experimental endotoxic shock induced by lipopolysaccharide (LPS) injection. Some of the behavioral effects of LPS, anorexia, depression...
The contribution of (R)-enantiomer of N-methyl-salsolinol (1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; NMSal) to the degeneration of dopaminergic neurons in the course of Parkinson's disease (PD) has been predominantly suggested by in vitro experiments in cell culture and by an in vivo study in which this compound has been directly injected into the rat striatum. The aim of the present...
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