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Protein tyrosine phosphatases (PTPs) have emerged as a new and promising class of signaling targets, since the discovery of PTP1B as a major drug target for diabetes and obesity. Blocking individual PTPs results in the activation of specific tyrosine phosphorylation events, but matching PTPs with such pathways and therapeutic indications is a complex undertaking. The history of PTP1B shows that its...
In recent years research on peritonitis has focused on the mesothelial lining of the peritoneal cavity. Activation of this cell-layer by direct contact with micro-organisms is known to influence coagulation, fibrinolysis and inflammatory processes. This review summarizes the recent advances in activation mechanisms of mesothelial cells by micro-organisms. Between bacterial species striking differences...
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