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ObjectiveTo summarize by meta‐analysis the accumulated data on the screening performance of second‐trimester sonographic markers for fetal trisomy 21.
MethodsWe conducted a literature search to identify studies between 1995 and September 2012 that provided data on the incidence of sonographic markers in trisomy 21 and euploid fetuses at 14–24 weeks' gestation. Weighted independent estimates of detection...
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