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The requirement of the activity of microsomal triglyceride transfer protein (MTP) for very low density lipoprotein (VLDL) secretion was determined using McA-RH7777 cells stably transfected with human Apo B48 (hB48). Secretion of VLDL containing hB48 (hB48-VLDL) by the transfected cells could be induced by exogenous oleate (0.4 mM), and oleate-dependent VLDL secretion could be selectively inhibited...
The vulnerable shoulder regions of human coronary atheromas contain increased number of degranulated mast cells and decreased number of smooth muscle cells (SMC). We have previously found that degranulated mast cells inhibit proliferation of SMC in vitro. Here we studied the possible role of mast cells as inductors of SMC apoptosis. For this purpose, rat serosal mast cells were isolated and induced...
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